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Glutathione disulfide, -L-glutamyl-L-cysteine, L-cysteinyl-glycine, and L-cystine with 13 C isotopes at C1 and C1 (L-Cystine-1,1- 13 C) were purchased from Sigma-Aldrich (St

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Importantly, the circadian interplay between PER2 and p53 forms a regulatory feedback loop in which p53 suppresses PER2 expression, while PER2 stabilizes p53 by inhibiting MDM2-dependent ubiquitination, linking circadian rhythm to cellular stress responses and tumor suppression (Gotoh et al., 2015

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