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Because this phase typically peaks and begins transitioning into the remodeling phase around the 21-to-30-day mark, a 4-week administration window provides the necessary stimulus exactly when the cellular machinery is most active [3, 5]

Obviously this ignores all those who require life long treatment due to other causes of B12 deficiency (of which there are many), thereby potentially causing great harm to the vast majority of their B12 deficient patients

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the fatty-acid modification supports once-weekly dosing