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LR3 enables interrogation of pathway dynamics across many hours to days

Experimental Dermatology

In addition, elevated functional biomarkers, including interleukin-2 (IL-2), interferon-gamma (IFN-), tumour necrosis factor (TNF), perforin (also known as pore-forming protein, PFP) and granzyme B (Gzms-B), further corroborated T cell activation and tumour killing (Supplementary Fig

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The initial rapid and short-lived release facilitated by Large Dense Core Vesicles (LDCVs) at the plasma membrane is followed by a sustained release of insulin that depends on the mobilization of insulin-secreting granules (ISGs) to the plasma membrane for exocytosis 1