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Long-term trials like LEADER confirmed cardiovascular and renal safety for liraglutide in T2D, with no increased risk of pancreatitis or thyroid malignancy [34]

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CagriSema (a combination of semaglutide and cagrilintide) is expected to seek regulatory approval in late 2025, and market overviews expect 1-2 new drugs entering the market every year for the next couple of years

By contrast, PD, which also has a prolonged prodromal stage similar to AD before the onset of motor symptoms, has a different progression of Lewy body pathology, which may take another decade to pervade the entire brain and cause significant, widespread neurodegeneration [102]