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The addition of GLP-1R activation modulates P13K/AKT/mTOR and ERK/MAPK pathways and indirectly alters JAK-STAT tone by reducing upstream cytokine signaling and modulation of STAT dimerization

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The electrochemical gradient normally drives K + + efflux from the epithelial cell into the lumen

In clinical studies, diarrhea wasnt a common side effect in people who took Januvia by itself

Pro-inflammatory cytokines disrupt neurotransmitter metabolism through mechanisms such as inhibited tryptophan conversion to serotonin while driving microglial activation, thereby amplifying neuroinflammation (271)