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Cosmos Study July 9, 2026 Dual-Team Study Team A:Kersten Bartelt, RNEric Barkley Team B:Blaine Franklin, PT, DPTJoe Deckert, PhD Key Findings Among adults who have had a documented substance overdose, those who started on a GLP-1 had a 39% lower risk of a repeat overdose within three years of their overdose compared to patients who were never prescribed a GLP-1

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10.1212/NXI.0000000000000565 Neurol Neuroimmunol Neuroinflamm

We therefore distinguish evidence domains explicitly, with relatively robust support for short-term metabolic benefit but substantially greater uncertainty for reproductive translation and periconception safety