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During the peak inflammatory phase, CIA mice developed severe arthritic symptoms and showed broader metabolic alterations in valine/leucine/isoleucine biosynthesis, phenylalanine/tyrosine/tryptophan biosynthesis, and arginine biosynthesis

The invention proposes the use of reduced glutathione encapsulated in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to improve symptoms in disease states related to diminished function of the methylation pathway, and also proposes combining methylcobalamin, and/or Insulin Growth Factor 1 (IGF-1) with liposomal reduced glutathione to accomplish such improvement

1977 Apr 15;33(4):548-52

Possible side effects, especially when consumed in large amounts or by supplementation, are summarized below: - Gastrointestinal discomfort: Some people report digestive symptoms such as diarrhea, gas or stomach upset after consuming sulforaphane supplements or large amounts of broccoli and other cruciferous vegetables