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189 Mitoferrin2-deficient female mice exhibited elevated hepatic TAG levels and altered hepatic lipid metabolism when exposed to a low-iron diet, suggesting that Mitoferrin2-mediated intrahepatic iron homeostasis plays an important role in lipid metabolism

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However, it is unclear exactly which isoform acts in cardiomyocytes and how it exerts its anti-ferroptosis effect, which requires further study