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136 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 For example, a study of more than 39,000 individuals from 13 longitudinal studies of aging found associations between good social connections (e.g., frequent contact with family and friends, having a confidante or never feeling lonely) and lower risk of dementia

Nguyen et al

World Psychiatry (2013) 12(2):928

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210,211 The activation of NF-B signaling is usually initiated by external stimuli such as cytokines or bacterial lipopolysaccharides, which bind to their corresponding receptors and trigger downstream signaling pathways