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471 According to the PAKT trial, the addition of the AKT inhibitor capivasertib to the first-line paclitaxel therapy for TNBC resulted in significantly longer PFS and OS, especially in tumors with PIK3CA/AKT1/PTEN alterations

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Quad-agonists and even more complex multi-receptor compounds are already in preclinical development

Other side effects The risk of hypoglycemia is generally low when these drugs are used alone or with metformin but rises when combined with insulin or sulfonylureas

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