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This makes it particularly harmful because it: delivers fatty acids directly to the liver worsens liver insulin resistance drives inflammation drives up sdLDL that cannot easily be removed by LDL receptors (and is principle cause of coronary artery disease) accelerates cardiovascular disease Visceral fat becomes both a marker of metabolic overload and a driver of further damage

A 2025 meta-analysis of 33 placebo-controlled randomized trials involving nearly 6,000 participants found that GLP-1RAs modestly (but significantly) reduced LDL cholesterol and total cholesterol, and interestingly, weight change did not influence these lipid outcomes

23 (5): 545-551 DOC ID 090006d180b7ff26