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Food and Drug Administration and request approval for orforglipron as a treatment for obesity by the end of 2025

Purifications were conducted by preparative RP-HPLC, eluting with a linear gradient (20 ml min 1 ) and using a binary solvent system consisting of H 2 O:MeCN:TFA (buffer A, 95:5:0.1

If symptoms persist or worsen, consult your healthcare provider

Wegovy is an FDA-approved medication for weight management

Since tirzepatide typically produces greater weight loss (20-25% body weight versus 15-17% with semaglutide at weight loss doses), more tirzepatide users may experience telogen effluvium simply because they lost more weight faster