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Right-upper-quadrant pain , especially if accompanied by fever or yellowing of the skin/eyes (jaundice), requires urgent assessment, as GLP-1 medications and weight loss can increase the risk of gallbladder disease

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After an initial loading regimen of 1mg three times weekly for two weeks, maintenance therapy is typically 1mg every three months for life in conditions like pernicious anaemia, or every two months if neurological involvement was present

lower doses are less likely to cause a clinically meaningful interaction than large doses