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In addition, ferroptosis also changes the inflammatory phenotype in macrophages (Ouyang et al., 2021), which promotes macrophage polarization and then aggravates inflammation (Yu et al., 2021)

However, Ozempic itself is not FDA approved to treat weight loss alone in patients without a diagnosis of type 2 diabetes

In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier

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Her BSL is 7.5 on arrival