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According to the MHRA-approved SmPC, the standard titration schedule is as follows: Weeks 14 : 0.25 mg once weekly (starting dose) Weeks 58 : 0.5 mg once weekly Weeks 912 : 1 mg once weekly Weeks 1316 : 1.7 mg once weekly Week 17 onwards : 2.4 mg once weekly (maintenance dose) At week 3, patients remain on the 0.25 mg dose

not all patients require escalation to the maximum 15 mg dose

Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Victoza Important Safety Information for Victoza WARNING: RISK OF THYROID C-CELL TUMORS Liraglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures in both genders of rats and mice

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