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It is typically prescribed alongside diet and exercise.[4] Trulicity is not approved for treating type 1 diabetes or diabetic ketoacidosis.[3] Trulicity Side Effects In clinical trials, approximately 5% of Trulicity patients experienced side effects.[4] The most commonly reported include: Diarrhea Nausea Abdominal pain Decreased appetite Vomiting Fatigue Some patients also experienced injection-site reactions