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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Validation of selected upregulated genes was performed by RT-qPCR and the induction of general antioxidant genes upon cystine withdrawal was confirmed (Figure 11D)

In the supraspinatus, chronic ischemia, mechanical unloading, and inflammation elevate mitochondrial ROS production, while antioxidant defenses-such as SODs, GPXs, and glutathione-are impaired, disrupting redox balance

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On one hand, Nrf2 activates downstream target genes to regulate iron metabolism-related genes, reducing intracellular free iron accumulation and Fenton reaction-induced oxidative damage (126130)