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Based on the available data, short-term effects related to MT-I and MT-II consist of the following [5, 18]: Nausea Facial flushing Fatigue Dizziness In addition, clinical studies on MT-II have reported several other specific side effects [19, 23]: Yawning Stretching Spontaneous erections Prolonged, painful erections (priapism) The administration of MT-I and MT-II can rarely cause reactions at the injection site, such as redness, swelling, and bleeding
This balance is crucial, as moderate ROS levels can activate pro-tumorigenic signaling pathways, including the PI3K/AKT and NF-B pathways, promoting cell survival, proliferation, and invasion 119,120
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