Unlike semaglutide, tirzepatide targets both GLP-1 and GIP (gastric inhibitory polypeptide) receptors, enhancing fat metabolism and insulin sensitivity
doi:10.1186/s12891-017-1571-8 11 Schneider B, Varghis N, Kennedy DJ
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Retatrutide works through triple incretin receptor agonism, while Tesamorelin drives growth hormone secretion via GHRH pathways, and AOD-9604 targets fat-specific lipolytic activity at the fragment level