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This might mean: Increased Absorption: In some cases, the slower transit time could actually increase the amount of medication absorbed

In addition, knockdown of mitochondrial NADH-generating citric acid cycle enzyme MDH2 in mice extended lifespan (Mao et al., 2025), which may have been due to an oxidizing shift in both the mitochondrial and cytoplasmic [NAD + ]/[NADH], although the potential mechanism driving the oxidation of the cytoplasmic [NAD + ]/[NADH] is unclear

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Two randomized trials of linaclotide for chronic constipation

The mitochondrial enzyme responsible for transforming pyruvate (pyruvate dehydrogenase) becomes inhibited, and pyruvate is instead shunted down an alternative pathway to yield lactate as a back-up route to maintain energy flow