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After interrogating both smooth muscle cell and endothelial cell function, we found that the protective effects of the supplement on vascular function in the rat are most apparent in the endothelium, as the sensitivity of mesenteric resistance arteries to smooth muscle vasoconstrictor agonists (phenylephrine and serotonin) and the endothelium-independent NO-donor sodium nitroprusside (SNP) were unchanged by Protandim supplementation