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A degraded lyophilised vial may appear yellowish rather than white, may fail to dissolve despite adequate water and time, or may produce a yellow-tinted solution

Management is supportive, with symptom monitoring and discontinuation of excess vitamin exposure

Common side effects include: Injection site reactions mild pain, redness, swelling, or bruising at the injection site, typically resolving within a few days Headache usually transient and manageable with standard analgesia Nausea or dizziness particularly in the initial treatment phase Skin reactions including itching, mild rash, or acneiform eruptions Temporary urine discolouration red or orange urine is harmless and expected Diarrhoea or flushing usually mild and self-limiting In patients with severe megaloblastic anaemia, low potassium levels (hypokalaemia) may occur during initial intensive treatment, but this is uncommon in routine maintenance therapy

Annals of Neurology 83 (1): 1326

Research use & handling + Supplied exclusively for in-vitro laboratory research and scientific study