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Introduced by Novo Nordisk in early 2026, this was the first oral GLP-1 medication approved specifically for weight loss, distinguishing it from other medications like Rybelsus that are approved only for type 2 diabetes

Potential effects of bariatric surgery on the incidence of heart failure and atrial fibrillation in patients with type 2 diabetes mellitus and obesity and on mortality in patients with preexisting heart failure: a nationwide, matched, observational cohort study

This results in the inactivation of NF-B-dependent inflammatory factors such as TNF- and IL-6, as well as the blockade of cell signaling molecules such as MAP kinases

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Some healthcare providers may consider adding orlistat to an existing GLP-1 regimen in patients who show weight loss plateaus after optimizing semaglutide dosing