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Pinto RA, Costa D, Morgado A et al: Intratrigonal onabotulinumtoxina improves bladder symptoms and quality of life in patients with bladder pain syndrome/interstitial cystitis: A pilot, single center, randomized, double-blind, placebo controlled trial

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Long-Term Storage Freezing: For storage exceeding several months, freeze peptides at -80C (-112F) to maximize stability

A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]