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The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo
Meanwhile, other classes such as insulins and dipeptidyl peptidase-4 (DPP4) inhibitors are rarely used as first-line therapies today, instead serving as follow-on options when additional control is needed
There is also a chance, however, that GLP-1s could interfere with the birth control pill
For type 2 diabetes , NICE NG28 recommends continuing GLP-1 treatment only if there is adequate response, defined as HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at 6 months
GLP1s are disrupting adjacent therapeutic markets
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