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However, baseline severity of denervation overall in a given cohort will profoundly impact whether or not improvement is anticipated and should be a key consideration in any trial design incorporating this as an outcome measure, as ceiling and floor effects may limit the usefulness of this assay in those of greater or lesser strength or age

Once diagnosis is established, no further treatment is required, with some cases exhibiting spontaneous regression after biopsy [1]

A role of the enzyme in modulating stress responses by controlling JNK activity was also proposed 56, 57

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