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These supplements were seen as a promising treatment due to their relative low cost of production and their low incidence of severe adverse effects

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(PubMed) Christen WG, Glynn RJ, Gaziano JM, et al

In Chinese guidelines, high serum levels of CK-18 fragments (M30 and M65) have been proposed as a possible indicator to perform a liver biopsy (60)

However, they commonly face challenges such as low bioavailability, complex action targets, difficulty achieving effective therapeutic concentrations in target tissues, and rapid in vivo metabolism