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Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity, and Metabolism, vol
Most of that added risk traced back to a specific, usually temporary kind of shedding called telogen effluvium, where physical or metabolic stress pushes hair into a resting phase and it falls out more than usual
Key considerations from available evidence: No direct hormonal mechanism linking tirzepatide to menstrual disruption has been identified Metabolic improvements (reduced insulin resistance, decreased androgens) may benefit women with PCOS The magnitude and rapidity of weight loss correlate with likelihood of temporary menstrual changes Long-term data on reproductive outcomes remain limited Healthcare providers should counsel women of reproductive age about potential menstrual changes when initiating tirzepatide
However, real-life analyses indicate a higher discontinuation rate, of approximately 70% stopping within 2 years, especially in non-diabetic patients (112, 113)
While the gastric emptying function of incretin mimetics may facilitate weight loss, it may have gastrointestinal effects and also impact the action of other medications taken orally
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