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Scoma et al., 2011)
The disease is caused by a mutation in the ATP7B gene, which codes for a protein that facilitates the incorporation of copper into proteins (such as ceruloplasmin) and also the transportation of copper into vesicles that allow it to be secreted in bile.1 The critical effect of a mutation in ATP7B is diminished copper secretion into bile, which leads to excess copper accumulation in the hepatocyte
DTLJ, the Montreal-based artist collaborative that created the Musical Swings, toured the Swings to four American cities, beginning with a one-month installation in West Palm Beach, Florida from February 4 to March 6, 2016
Methods: Participants with first lacunar or mild cortical ischaemic stroke underwent brain magnetic resonance imaging (MRI) at diagnosis, then brain MRI and macular optical coherence tomography angiography (OCTA) at baseline, 3-, 6-, and 12-months
Unlike domestic FDA guidance, ICH E6(R3) carries harmonized weight across FDA, EMA, PMDA, and MHRA-regulated trial submissions, enabling sponsors to design global protocols against a single set of GCP principles rather than navigating jurisdiction-specific interpretations
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