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5.6 Necrotizing Fasciitis of the Perineum (Fourniers Gangrene) Reports of necrotizing fasciitis of the perineum (Fourniers Gangrene), a rare but serious and life-threatening necrotizing infection requiring urgent surgical intervention, have been identified in postmarketing surveillance in patients with diabetes mellitus receiving SGLT2 inhibitors, including dapagliflozin

Furthermore, GLP-1 has been shown to stimulate calcitonin secretion from the thyroid gland, which may further contribute to protective effects on bone, 25 but whether this action is relevant in humans still needs to be clarified

Maar, K., Hetenyi, R., Maar, S., Faskerti, G., Hanna, D., Lippai, B., Takatsy, A., & Bock-Marquette, I

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Based on animal study timelines, vascular and cellular effects may begin within the first week of treatment