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In addition, tumor necrosis factor (TNF) binding to TNFRSF1B activates TRAF2/MAPK signaling, enhances TRPV1 and SCN10A expression, and thereby facilitates NPP development in sequence ( 8 Cellular basis of synaptic plasticity mediated by activated non-neuronal cells 8.1 Pro-inflammatory cytokines Pro-inflammatory cytokines (PICs), such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor - (TNF-), have been reported to be positively associated with NPP

doi: 10.1177/1470320316655037

Gorman, B

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Growth hormone and IGF-1 are also fundamental in skeletal growth during puberty, namely given that IGF-1 causes increased uptake of amino acids and nutrients, in particular collagen