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Prof Sir Stephen ORahilly, a professor of clinical biochemistry and medicine at Cambridge University, said that given increasing rates of dangerous weight gain, medicines such as tirzepatide will become a central plank of how we help people living with obesity to live longer and healthier lives

Preclinical studies have already demonstrated the beneficial effects of GLP-1 on myocardium and vascular endothelium, and many clinical studies evaluating changes in surrogate markers of CVD have suggested potential benefits from the use of GLP-1 RAs

The role of energy homeostasis in depression pathophysiology and its heterogeneity

The regulatory features of BCAAs in macrophage polarization are mainly reflected in their role as an intersection node linking nutrient sensing-mTOR signaling-energy metabolic coupling. After entering cells, BCAAs can be converted by BCAT into branched-chain -keto acids, which are further catabolized by the BCKDH complex to generate products such as acetyl-CoA, succinyl-CoA, or propionyl-CoA, thereby connecting to the supply of TCA cycle intermediates and mitochondrial oxidative metabolism (62)