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Introduction Glutathione S -transferases (GSTs) refer to a group of cytosolic phase II detoxification enzymes, which have both a GSH-binding site and a substrate-binding site (H-site) that catalyze the nucleophilic attack of the sulfur atom of glutathione (GSH) on electrophilic groups of substrate molecules ( S -transferase Pi (GSTP) is the most abundant member of cytosolic GSTs in the mammalian cells ( via its non-catalytic ligand-binding activity

This was reinforced by the observation that diabetes improved when patients were given insulin

Comparative investigations assessing synergistic interactions with conventional antidepressants, as well as direct comparisons among various herbal supplements, would further bolster the evidentiary foundation