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Additionally, these drugs suppress glucagon secretion (a hormone that raises blood glucose), slow gastric emptying to reduce post-meal glucose spikes, and act on appetite centres in the brain to promote satiety and reduce food intake

These benefits begin early, even before dramatic weight loss

[32] The AR acetylation site is a key target of NAD-dependent and TSA-dependent histone deacetylases [33] and long non-coding RNA

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PMID 29208439