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In an attempt to uncover the direct relationship between insulin resistance and the PD etiology, recent research investigated the effects of insulin resistance in a MitoPark mouse model of PD in vitro, in vivo, and ex vivo [156]

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These 15 altered metabolomics pathways resulted in increased levels of glutamate, 4-Aminobutanoate, carnosine, thymine, porphobilinogen, homogentisate and 4-Guanidinobutanoate in the R group ( Figure 5B , Supplementary Figure 4A )