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Morphologically, the most typical alterations in ferroptotic cells are concentrated in mitochondria, characterized by a marked reduction in mitochondrial volume, increased membrane density, and reduction or disappearance of mitochondrial cristae, while the nucleus remains relatively intact, lacking apoptotic features like chromatin condensation or nuclear membrane rupture (Wang et al., 2020)

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for two primary indications

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