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Siah2 inhibition decreased AKR1C3 expression, intracellular androgen levels, and inhibited cell growth, while AKR1C3 re-expression in Siah2 knockdown cells elevated Siah2 protein levels

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In comparison, an emerging treatment with potential therapeutic application, in the form of a pentadecapeptide known as BPC 157 (body protection compound), appears to be somewhat unrestricted by the limitations seen in previous therapies