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In addition, several studies have shown that so-called nascent neurons generated in the presence of NeuroD1 are actually endogenous neurons, as many NeuroD1-mediated mCherry-positive neurons overlap with GFP-prelabelled endogenous neurons

Calculations are shown for both the 5 days/week and 3 times/week schedules

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The grounds for the ruling were that the experimental data contained in the patent documents were insufficient to substantiate its inventiveness, and that the submission of supplementary experimental evidence would not be permitted