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For the second group, those with a pre-existing substance use disorder, the researchers tracked which of the 81,617 participants experienced drug-related emergency department visits, hospitalization, mortality, overdose, or suicidal ideation or attempt

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The impairment and uncoupling of ETC leads to the excessive generation of ROS, which further trigger a series of cellular injuries

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39-41 For example, a particular increase in SOCS3 expression is observed in ARC neurons of mice with diet-induced obesity and this may be a key cause of leptin resistance