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This information enables us to elucidate the effects of individual mutations and provide us with the genotype-phenotype correlation ( + binding site may cause more detrimental effects compared to mutations of residues in other less conserved sites

NAD+ does more than produce energy - it acts as a co-substrate for enzymes such as sirtuins and PARPs that maintain DNA repair and genomic stability

NCI- Translational Res Conference, 2011

Bezerra, D

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