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Figure 1 Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

For some patients, the driver may be less about serotonin and more about inflammation, sleep disruption, and systemic physiology

The deficiency of thiamine can aggravate sciatic nerve pain leading to more severe symptoms

Nutritional support could come from: a dietician GP formalised online nutrition programs such as Noom or MyFitnessPal

Upcoming Biosimilars: With semaglutide's patent set to expire around 2032, several generic and biotech companies are preparing to introduce biosimilar versions