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These metabolic regulations meet the high glutamine demand of proliferating tumor cells, which supports tumor growth by facilitating both energy production and the biosynthesis of building materials

According to the guidelines, SGLT2 inhibitors should be discontinued before surgery and avoided during severe illness until their safety and effectiveness are firmly established [12]

Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break

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Continuing treatment maintains the achieved weight loss and sustained metabolic benefits rather than producing endless further loss