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Figure 1 3.1.2 Preparation process of DOXHCl solution In the prescription study, it was found that doxycycline hyclate dissolved incompletely when the solution was prepared at room temperature, indicating that the preparation of the product required certain heating conditions

Comment: Many commenters did not support mandatory participation for ASM, noting their belief that the model could impose significant financial risks and administrative burdens which are inappropriate since this is a new, untested performance framework that still has measures in development

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doi: 10.1016/j.biopha.2024.117691 86 JimenezMFlandesJvan der HeijdenENgCSHIdingJSGarcia-HierroJFet al