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This gradient mechanismranging from low-concentration signaling blockade to high-concentration multi-pathway synergyexhibits concentration-dependent anti-inflammatory activity in LPS-stimulated HaCaT keratinocytes (1.520 M), with no cytotoxicity observed below 6 M (Nguyen et al., 2022)

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J Alzheimers Dis 42(s3):S125S152 Raghavendra V, Kulkarni SK (2001) Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks