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5) Emotional Trauma: Chronic stress and unresolved trauma cause dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis and suppress mitochondrial function, contributing to chronic fatigue

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[66] The FDA has not evaluated these for safety and effectiveness and they are thus considered not to have been shown to be safe or effective

[DOI] [PubMed] [Google Scholar] 16.Tonelli M., Wiebe N., Culleton B., House A., Rabbat C., Fok M., et al

Strategy 3: Consider Licensed Compounded Semaglutide For patients without commercial insurance and ineligible for Medicaid, compounded semaglutide 2.4 mg through a PCAB-accredited Michigan 503A pharmacy at ~$199/month offers clinically equivalent active ingredient at a substantially lower price, with the caveats about compounding oversight described above