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The IWRS allocated dispensing unit numbers for each patient, with the trial product dispensed by the site investigator or study coordinator at the trial site visits

those at intermediate or high risk may proceed to Enhanced Liver Fibrosis (ELF) testing or FibroScan, with referral to hepatology for those with suspected advanced fibrosis, in line with NICE guidance (NG49)

b , Representative micrograph of the TT-OAD2GLP-1RG s complex

for 5% of patients, 1.7 mg was the maximum tolerated dose

Decreased butyrate alters the immune function and intestinal permeability of the intestinal mucosa, leading to a compromised intestinal barrier, where bacteria and their metabolites can enter the bloodstream and reach the distant target tissues of the host, resulting in local inflammation and aggravating arthritis (He et al., 2022)