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L.JaitinD.WieghoferP.StaszewskiO.DavidE

Mechanism of Action Selective agonist of the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs, stimulating GH release without significantly affecting cortisol, prolactin, or ACTH levels

Based on the presentation of symptoms, Rome criteria further categorize primary chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C) [5]

The key variable is how much each macronutrient slows gastric emptying

This may include taking supplements such as folate and vitamin B12, which can help lower homocysteine levels and support methylation