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Semaglutide belongs to a class of medications known as GLP-1 receptor agonists, which work by mimicking a natural hormone in your body, glucagon-like peptide-1 (GLP-1)

At present, several DPP-4resistant GLP-1R agonists and numerous DPP-4 inhibitors (DPP-4i) have been approved for the treatment of type 2 diabetes (T2D) and are widely used

2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines

Gastrointestinal (GI): Nausea is the most common side effect and tends to be dose-dependent

4 Current therapeutic landscape and unmet need While resmetirom (a THR- agonist) has recently gained FDA approval for the treatment of MASH (in patients with fibrosis F2-F3), marking the first-ever pharmacological agent for this condition (Liu et al., 2025), there remains no single FDA-approved drug that effectively prevents or reverses the progression of advanced SLD to HCC