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Her Stable Weight Loss study is a 72-week research project designed to test the long-term effect of the weight loss medication semaglutide on eating behaviour, hunger and food liking, as compared to placebo

These concerns are not unfounded, as the medications mechanismslowing gastric emptying and altering hormone levelscould theoretically impact bile flow and composition, potentially leading to gallbladder complications

The exposure group was defined as the initiation of semaglutide treatment after their diagnosis of type 2 diabetes

The FDA has approved oral semaglutide for two indications: as Rybelsus for the treatment of type 2 diabetes in adults, and as Wegovy pill for chronic weight management in adults

Retatrutide holds no MHRA or EMA marketing authorisation as of 2026