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Neutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production

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Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) complex 1, exhibits cardioprotective effects in ferroptotic cells, where mTOR overexpression protects against iron-overload-induced cell death, a process exacerbated by mTOR deficiency (67, 68)

Clearly there is a particular type of FMS patient who presents with increased sympathetic nervous system function, anxiety and/or depression, and a history of poor sleep with associated fatigue and widespread soft-tissue tenderness